International Conference on Diabetes and Cholesterol Metabolism

Among the numerous complications frequently connected with diabetes, one of the foremost mystifying and painful is the frozen shoulder. Adhesive capsulitis , the condition’s biological term, is a pathological condition of the shoulder joint which causes the painful and gradual loss of motion. The connective tissue of the shoulder joint inflames and stiffens, causing chronic pain, limiting mobility and disturbing sleep. The associated pain varies between sharp stings that radiate through the bicep to dull ache. Link between diabetes and frozen shoulder: There’s no conclusive connect link between the shoulder condition and the disease. Few studies indicate frozen shoulder is caused by glycosylation of the collagen in the shoulder joint.  What Happens to the Shoulder? Adhesive capsulitis is characterized by three stages, in spite of the fact that the severity and length of the stages may vary from individuals to individuals. ·      ...

A bioartificial pancreas —a device that supports and encapsulates islets of Langerhans— replaces the beta cells and islets which were destroyed by type 1 diabetes. Implanted in the peritoneal cavity or under the skin, it contains approximately a million islets. It responds to changing blood glucose levels by releasing hormones, mainly insulin. Every bioartificial pancreas is manufactured from non-living and living components. The living component is the islets, which secrete insulin concurring to typical physiology by sensing glucose levels. The non-living component shields the islets from the diabetic’s body and its destructive immune mechanisms, however grants the islets inside to thrive. There are several types of bioartificial pancreas which includes microencapsulated , or coated islets are the first-generation bioartificial pancreas. Their advantage is that nutrients can effectively move into the islets and insulin can move out. Among the downsides is that they are diff...

The maintenance of blood glucose in a limit run requires tight coupling among circulating insulin secretion, proinsulin biosynthesis and nutrients. Glucose, the most physiological stimulus for insulin secretion, controls insulin release through activities on so-called triggering and amplifying pathways in the β-cell. The ATP-sensitive K+ (K+-ATP) channels are key players within the activating pathway. Their activity is directed by the mitochondrial oxidative phosphorylation of glucose metabolites, which comes about in an increased cytosolic ATP to ADP ratio, hence restraining potassium efflux through the channel, depolarizing the plasma membrane, and opening voltage-dependent L-type calcium channels, which increments cytosolic calcium and leads to exocytosis of insulin. In addition to the triggering pathway, the β-cell displays pathways downstream to the K + -ATP channel, which increases insulin secretion to abdicate physiological levels of the hormone in response to glucose. T...

Familial hypercholesterolemia is a genetic disorder. It is caused by a defect on chromosome 19. It causes LDL (Low Density Lipoprotein) cholesterol level to be very high. The deformity makes the body incapable to remove LDL (bad) cholesterol from the blood. This results in a high level of LDL in the blood.  The condition is typically passed down through families in an  autosomal dominant  way. This means you merely need to get the abnormal gene from one parent in order to acquire the disease.  In uncommon cases, a child may acquire the gene from both parents. When this happens, the increase in cholesterol level is much more severe. The risk for heart attacks and heart disease are high, even in childhood. High cholesterol became a very common medical condition, but it's frequently the result of unhealthy lifestyle choices, and thus treatable and preventable. With familial hypercholesterolemia, a person's chance of high cholesterol is higher because a defec...